SemaglutideA GLP-1 receptor agonist peptide drug for type 2 diabetes and chronic weight management. In Canada it is a prescription…Authorized in Canada (prescription)
TirzepatideA dual GIP/GLP-1 receptor agonist. Health Canada has authorized Mounjaro for type 2 diabetes and Zepbound for chronic…Authorized in Canada (prescription)
RetatrutideAn investigational triple-hormone (GIP, GLP-1, glucagon) receptor agonist from Eli Lilly. It is not approved anywhere,…Not authorized in Canada
LiraglutideAn older, once-daily GLP-1 receptor agonist. Victoza (type 2 diabetes) and Saxenda (weight management) are authorized…Authorized in Canada (prescription)
InsulinInsulin is the best-known peptide hormone, discovered and first used as a treatment in Toronto in 1921–22. It is an…Authorized in Canada (prescription)
AOD-9604A fragment of human growth hormone developed as an anti-obesity pill. Its larger Phase 2b trial failed and obesity…Not authorized in Canada
HGH Fragment 176-191A piece of the growth hormone molecule marketed for fat loss. It is closely related to AOD-9604, whose obesity trial…Not authorized in CanadaEvidence at a glance
Status and evidence table
| Peptide | Canada status | Human evidence |
|---|---|---|
| Semaglutide | Authorized in Canada (prescription) | Strong: large randomized human trials |
| Tirzepatide | Authorized in Canada (prescription) | Strong: large randomized human trials |
| Retatrutide | Not authorized in Canada | Moderate: some randomized human trials, specific uses (still investigational) |
| Liraglutide | Authorized in Canada (prescription) | Strong: large randomized human trials |
| Insulin | Authorized in Canada (prescription) | Strong: large randomized human trials |
| AOD-9604 | Not authorized in Canada | Failed: the larger Phase 2b trial did not show weight loss |
| HGH Fragment 176-191 | Not authorized in Canada | Very limited: almost all animal or cell studies |
Status reflects Health Canada's peptide pages, its April 2026 advisory and the Drug Product Database as checked on November 10, 2026. Authorized products carry an 8-digit DIN (drugs) or NPN (natural health products).