Canada Peptide Guide
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Longevity

Longevity & mitochondrial peptides

Epitalon, MOTS-c, humanin and SS-31: interesting biology, very little human evidence (one US approval for a rare disease).

4 peptides0 authorized in Canada4 not authorized / other
Longevity peptides: illustration
Epitalon (Epithalon) peptide illustrationEpitalon (Epithalon)A 4-amino-acid peptide based on a pineal gland extract, promoted for "telomere" anti-ageing. Research comes largely…Not authorized in CanadaMOTS-c peptide illustrationMOTS-cA 16-amino-acid peptide encoded in mitochondrial DNA, studied for metabolism. A 2023 review says no effective clinical…Not authorized in CanadaHumanin peptide illustrationHumaninA mitochondrial-derived peptide studied in ageing research. Human studies measure natural blood levels; we found no…Not authorized in CanadaSS-31 (Elamipretide) peptide illustrationSS-31 (Elamipretide)A mitochondria-targeting peptide that received FDA accelerated approval in September 2025 for Barth syndrome, an…Not authorized in Canada (approved elsewhere)

Evidence at a glance

How many peptides in this category reach each level of human evidence (our rating, see each page for sources).

Large randomized trials0
Some randomized trials0
Small human studies1
Cell & animal only3

Status and evidence table

PeptideCanada statusHuman evidence
Epitalon (Epithalon)Not authorized in Canada Very limited: almost all animal or cell studies
MOTS-cNot authorized in Canada Very limited: almost all animal or cell studies
HumaninNot authorized in Canada Very limited: almost all animal or cell studies
SS-31 (Elamipretide)Not authorized in Canada (approved elsewhere) Limited: small or low-quality human studies (rare disease; accelerated approval)
Status reflects Health Canada's peptide pages, its April 2026 advisory and the Drug Product Database as checked on November 10, 2026. Authorized products carry an 8-digit DIN (drugs) or NPN (natural health products).