In short
An angiotensin IV analog developed in a university lab for Alzheimer's and Parkinson's research. Animal data only; we found no published human trials. Not authorized in Canada.
Also known asangiotensin IV analog
CategoryBrain & sleep
Canada statusNot authorized in Canada
Human evidence Very limited: almost all animal or cell studies
Last reviewedNovember 10, 2026
How strong is the human evidence?
- Cell & animal
- Small human studies
- Some randomized trials
- Large randomized trials
What is Dihexa?
Its developers describe dihexa as a metabolically stable small-molecule angiotensin IV analog that crosses into the brain and promoted new synapses in animal models (Wright, Kawas & Harding 2015).
Is Dihexa legal in Canada?
Not authorized: no product found in Health Canada's Drug Product Database.
What the research shows
- Rodent studies report improved memory measures (e.g. Sun et al. 2021, Alzheimer's mouse model).
What it doesn't show
- We found no published human clinical trials of dihexa (PubMed search, Nov 2026).
Common questions
Is dihexa a peptide?
It is derived from the peptide angiotensin IV, but its developers describe it as a small-molecule analog.
Is dihexa safe?
There are no human safety data.
Sources
- Health Canada Drug Product Database (searched Nov 10, 2026)
- Wright JW et al. Development of small molecule angiotensin IV analogs (Dihexa). Prog Neurobiol 2015
- Sun X et al. Dihexa rescues cognitive impairment in APP/PS1 mice. Brain Sci 2021
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